UDK 631.51
Modern problems of the application of different systems and methods of primary tillage
I.G. Pykhtin, A.V. Gostev
Summary. The authors` modern views of classifying systems and methods of primary tillage in crop rotations, conditions of their effective application are given; changes of some conceptual terms are suggested.
Keywords: tillage, concepts, conceptions, classification, tillage systems, tillage methods.

UDK 631.879.32:631.41:631.453
Influence waste of dolomite flour on the physicochemical properties of acid soils and their chemical resistance
V.I. Titova, E.V. Dabakhova, N.A. Korchenkina, A.M. Arkhangelskaya
Summary. Studies conducted in laboratory model experiments with the waste product of dolomite flour showed that the material under study clearly has the neutralizing ability potential. It is established that the use of waste at the soddy-podzolic and light gray forest soil contributed to the improvement of its physical and chemical properties: reduction of acidity, increase the degree of base saturation and acid-buffering capacity. The maximum improvement effect was noted with the introduction of the waste at the dose of 20 t/ha and in the majority of the cases it depended on the size of fractions. It was revealed that the use of waste reduced the mobility of copper in the soil, as well as its accumulation by the wheat, and promoted the increase of the experimental culture biomass.
Keywords: waste, lime material, soil properties, copper, phytotoxicity, detoxification of the soil, wheat.

UDK 633.11/.14«324»:631.82
Mineral fertilizers and biopreparations influence on yield of winter wheat and rye in forest-step of Middle Volga region
V.I. Kargin, A.A. Erofeev, A.G. Makarenkina, I.A. Latyshova, N.A. Perov
Summary. The aim of this research was the identification of mineral fertilizers and biological products for new winter crop varieties. It has been found when such varieties as winter rye “Estafeta Tatarstan” (Tatarstan’s Relay) and winter wheat “Volzhskay Kachestvennaya” (Volga Quality) was cultivated on leached well-phosphored and well-potassiumed black soil (chernozem) the highest crop yield was formed under 60% of nitrogen, 100% of phosphor and 60% of potassium removal condition. Increasing of winter wheat yield under these conditions was 1,15–1,23 t/h and winter wheat 0,99–1,16 t/ha in compare with common benchmarks. Biological fertilizers were effective under low values of mineral fertilizers. High conjugation cenosis capacity with yields was established (g2 = 0,88–0,96). It allows to use this indicator for identification of optimal fertilizers doses to create optimal balance between quantity of productive stalk and grains quantity in ear.
Keywords: fertilizer system, yield, winter wheat, winter rye, leached black soil, cenosis capacity.

UDK 631.862.1+631.87
Effect aftereffect organic fertilizers and inoculation rizoagrin seeds on accumulation vegetable remains and productivity of wheat
S.N. Nikitin
Summary.In 2006-2008 biennium. studied the effectiveness of different kinds of organic manure and presowing treatment of wheat seed with rizoagrin. The purpose of the research was to develop practical suggestions for environmentally sound and efficient use of different types of organic fertilizers and crop productivity. Studies have shown that the aftereffect of different kinds of organic manure and presowing seed rizoagrin enhance accumulation and chemical composition of crop residues, byproducts and spring wheat. The amount of by-product of spring wheat in the first year of organic fertilizer increases relative to controls at 0.36 -0.74 t/ha (4.12 control t/ha). When you apply the rizoagrina amid different kinds of organic manure quantity of straw varied -5.17 4.83 t/ha. To plant wheat residues in the soil remains 17-23 kg/ha of nitrogen. Joint application of biological and organic fertilizers to 21-25 kg/ha. The greatest quantity of NPK comes when applying high doses of organic fertilizers. Nitrogen control in grain was 70.27 kg/ha. When applying organic fertilizers increased by 6.69 -22.66 kg/ha. Joint application of Biopreparations and organic fertilizers, this figure had risen to 13.55 -33.85 kg/ha. The maximum nitrogen was in the inoculation of rizoagrinom against the backdrop of high doses of organic fertilizers. Increase the yield of different types of organic fertilizers amounted to 0.3 -0.64 t/ha or -22.2 10.4%. Higher doses of organic fertilizers have contributed to obtain yields at 3.46 -3.52 t/ha, while control of 2.88 tons/HA. Joint application of Biopreparations and organic fertilizer on wheat yield increases by 0.5 -0.95 t/ha. Established that the aftereffect of the various kinds of organic fertilizer and preplant seed treatment biopreparat RIZOAGRIN increase the accumulation of vegetable remains residues, straw, their nitrogen content and yield of spring wheat. The greatest flow of nutrients into the soil with vegetable remains and productivity of spring wheat contributed to the aftereffect of sewage sludge and animal manure in high doses in combination with pre-treatment of seeds biopreparat RIZOAGRIN.
Keywords: organic fertilizers, biological product, crop residues, productivity, rizoagrin, spring wheat.

UDK 631.874:633.2
Role of biological fertilizers in the restoration of waste lands
I.E. Soldatova, B.A. Abaeva
Summary. Studies on the eroded mountain-meadow black soils showed that against the background of natural fertility complex fertilizer application of CMF, ekstrasol and gumimaks as a 0.1per cent solution at the beginning of vegetation and tillering of grasses increased the grass height from 34 cm to 58 cm and development of 1540 shoots per 1 sq m (projective soil cove reached 91 % to 34 % in control). In the same variant the highest underground mass (5.04 t dry matter per 1 ha) and biological activity of soil microorganisms (the number of root nodules for one plant of meadow clover increased from 8 to 37 pieces, the degree of cellulose decomposition enlarged from 18.5 to 34.1 per cent) were noted. The usage of studied biological preparations contributed to the increase in the proportion of gramineous and leguminous grasses in the phytocenosis. Stocky leguminous grasses, which were 1.5 %  of  herbage, gave place to tall (red and honey clover) and average tall (vetch and locoweed) plants under the influence of the biopreparators, which increased legume part to 14 %. At the same time the number of motley grasses decreased from 74.6 to 32.8 %. As a result the productivity of greenlands increased from 536 to 1810...2226 feed units per hectare, the yield of digestible protein enlarged from 0.36 to 1.34...1.91 centners/ha. Concentration of exchange energy increased from 6.4 GJ/ha to 21.7...26.9 GJ/ha. Despite more intensive growth and development of phytocenosis against the background of N60Р45К29, application of mineral fertilizers decreased activity of soil microflora (cellulose decomposition was 14.5...30.0 %). However, when you use mentioned combination, nitrogen accumulation in soil is 74.3 kg/ha.
Keywords: under price lands, degradation fitocenosis, herbage, soil, bioactivity, CMF (complex mineral fertilizer), Extrasol, Gymimax.

UDK 633.853.52:631.526.32(571.63)
Cоmparative evaluation of high productive soybean varieties in the conditions of the Far Eastern south
O.I. Khasbiullina, N.V. Mudrik, K.S. Butovets
Summary. The main goal of the research included the competitive evaluation of high productive soybean varieties while using different methods of biological statistics both in the production cultivation and in the selection process taking into account regional peculiarities and climatic conditions. While testing the varieties on the reaction to the testing conditions change there were determined stable varieties – Primorskaya 13, Venera, Primorskaya 301. They refer to the early and mid-ripen groups. As for the varieties with high potential under improving of testing conditions Primorskaya 96, Primorskaya 69, Primorskaya 86 and Primorskaya 4, refer to the mid and late ripen groups. There was given the total evaluation of eleven soybean varieties according to Martynov’s method. It characterizes the given group according to the deviation from the goal optimum of the breeder. In the given case the total evaluation was calculated according to the seven characteristics: the two years yield, the plant height, vegetation period, oil and protein content in the seeds, the disease resistance. As a result of the research the least average deviation from the goal have varieties: Primorskaya96, Primorskaya 4, and Primorskaya 86. These varieties are under the State testing now. Usage of different methods of biological statistics can be considered as the breeder’s opportunity extension in evaluation and the best varieties choice taking into account the standard characteristics of the variety features given as the breeder’s goal.
Keywords: soybean, variety, ecological plasticity, total evaluation, variety model, selection process.

UDK 635.21.632.3.38
Influence of the periods of the removal of vegetable tops on quality and productivity of the seed potatoes
N.A. Lapshinov T.V. Ryabtseva
Summary. Are represented the results of studies on the establishment of the optimum periods of the removal of the vegetable tops of potatoes, based on the data about the dynamics of the propagation of the flying generation rot and the periods of the tuber formation of seed fraction under the conditions of the northern wooded plain of West Siberia. Minimum defeat by the virus infection of potatoes with the early periods of the removal of vegetable tops (on August 13 to 20). With the interval in are 5th 7 days, with the second period of the angling of vegetable tops occurs the growth of infection on the plants to 2,3 – 2,8%, in 10 days the number of plants of those struck by viruses increases by 6,7… by 5,7%. The period of the angling of vegetable tops had a significant effect on the productivity of potatoes – 41,4%. The conditions, which are folded in the period of the vegetation of potatoes also determined its productivity, the portion of the influence of factor medium – 22,7%, interaction of factors type and medium – 16,9%. With the removal of vegetable tops in potatoes on August 25 to 30, the productivity increases by 28,3 – 37,4%, in the comparison with the early periods, but in this case it occurs to the accumulation of virus infection in the concealed form on the sheet photosynthetic apparatus to 11,4-21,7% respectively. 
Keywords: potatoes, virus diseases, productivity, potato and peach aphis, the periods of the harvesting.

UDK 619:615.033:615.28:637
Veterinary control of residues of drugs in livestock production on the example of drugs  based on ciminal
S.V. Shabunin, G.A. Vostroilova, G.N. Bliznetsova
Summary. Usage of drugs in animal husbandry and veterinary medicine is a modern reality. Therefore, the domestic producers of agricultural products, using in accordance with its technological regulations antibiotics, pesticides and growth stimulants, should guarantee the safety of products for human health. The developed way of the fullest extraction and a high-sensitivity method of tracking down ciminal in the muscle tissue, parenchymatous organs and milk, allowed to study the residual quantities of preparations сidisept-о and сidisept-gel in livestock products. In the experiment it was found that the absorption of the active substance in the organs and tissues depends on the dosage form of the product and the way of its application. A day after the last injection of сidisept-о residual quantities of ciminal are determined in all the organs and body fluids of pigs. The largest number of ciminal was found in the liver (8,55±0,22 mkg/g). Then, on the concentration organs and body fluids are distributed as follows: the kidneys (7,04±0,65 mkg/g) – urine (6,63±0,37 mkg/ml) – lungs (5,79±0,29 mkg/g) – blood (3,69±0,31 mkg/ml) – muscles (1,42±0,11 mkg/g). After 3 days marked by a sharp decline in the concentration of the drug in tissues and organs. In this term studies of trace amounts of the drug are detected in the muscles. On the 7th day after the last injection of the drug ciminal absent in all organs, tissues and body fluids of pigs. Thus, in the application of сidisept-о slaughtering of animals for meat may be permitted not earlier than in 7 days after last introduction of the preparation. When an external application of сidisept-gel time of slaughtering of animals for meat and use of milk and other products after processing of the preparation is not limited. 
Keywords: ciminal, pigs, cows, residues, time frames.

UDK 636.4.084
Effect of preparations selenium and iodine in combination with probiotic on the balance of nitrogen, calcium and phosphorus in the diet of young growth of pigs for fattening
S.N. Rassolov
Summary. In experiments on animal and clinical researches it is established that infringement of formation of the intestinal environment negatively affects an absorption especially on mastering of mineral substances, vitamins, and finally on an immunity condition. The purpose of the present work – comparative efficiency of influence of preparations of selenium and iodine in a complex with probiotic on balance of nitrogen, calcium and phosphorus of a diet of young growth of pigs. From 3 monthly age of a condition of the maintenance and feeding for experimental groups were identical, but to animals of I skilled group hypodermically unitary implanted iodine in a dose of 9,0 mg/goal, перорально 0,5 mg/goal of selenit of sodium and probiotic Sib-Mos in a dose 1 г on 1 kg of mixed fodder, to II skilled group entered intramuscularly unitary a preparation sedimin in a dose of 5 ml on a head and  probiotic Sib-Mos in a dose 1 г on 1 kg of mixed fodder, an animal of III skilled group entered intramuscularly unitary a preparation seledant in a dose of weight of a body of 20 mkg/kg + probiotic  Sib-Mos in a dose 1 г on 1 kg of mixed fodder. As a result of the spent researches the balance and use of nitrogen, calcium and phosphorus was the best at the animals of II skilled group receiving unitary a preparation sedimin in a dose of 5 ml on a head + probiotic Sib-Mos in a dose 1 г on 1 kg of mixed fodder. So, in the given group the percent of use of nitrogen was above on 9,30 %, calcium on 4,7 %, phosphorus on 6,2 % in relation to animals of control group that testifies to an intensification of albuminous and mineral exchanges in an organism of animals. Thus, it is established that at young growth of pigs under the influence of selenium and iodine preparations in a combination with probiotic the positive balance of nitrogen, calcium and phosphorus that testifies to an intensification of albuminous and mineral exchanges in an organism of animals and as consequence – about increase of their efficiency is noticed.
Keywords: pigs, probiotic, iodine, selenium, balance, nitrogen, calcium, phosphorus, efficiency, metabolism.

UDK 636.085/.087:632.4:636.2 (470.32)
Contamination mycotocxins forages for a horned cattle in economy Central chernozem region
L.I. Efanova, O.A. Manzhurina, V.I. Morgunova, M.I. Adodina, T.S. Frolova, A.V. Stepanov
Summary. Monitoring on the basis of generalization of results mycologic and toxicological the analysis of toxicological safety of rough and juicy forages for a horned cattle, arrived for research in 2007…2011 in laboratory of diagnostics infectious and and parasitic diseases of animals, All-Russian Veterinary Pathology Pharmacology and Therapy Research Institute from cattle breeding economy central chernozem zones with the raised disease of cows and newborn calfs is moved. 307 tests of forages for different sexual and age groups of a horned cattle of 68 economy of 7 areas of the Russian Federation (Voronezh, Lipetsk, Belgorod, Tula, Oryol, Kursk, Tambov) on presence of aflatoxin В1, ochratoxin А1, Т-2 toxin, zearalenon, deoxynivalenol (Don), fumonisin В1 by a method the immunefermental analysis (IFA) are investigated. The wide circulation contamination forages is established by metabolites of microscopic mushrooms. Only 8,8 % of tests have appeared free from mycotocxins; In 2,3 % – level mycotocxins has exceeded maximum concentration limit, in the others of 88,9 % it is revealed from 1 to 5 mycotocxins simultaneously. Real danger to an organism is represented by forages, contamination simultaneously several (2…5) mycotocxins (69,7 %) even in maximum concentration limit, т.к at highly productive cows were marked a toxic dystrophy of a liver (28 %) and infringement of function of kidneys (64 %). Most contamination from all kinds of forages there was a monoforage, 2 and more mycotocxins in it is revealed in 89,4 % of cases. 
Among revealed mycotocxins in forages metabolites fusarium mushrooms were dominating: Don – is found out in 99,4 % the investigated tests, zearalenon – 62,5 %; Т-2 toxin – 44,5 %. Concentration in the investigated forages has made Don – of 0,001…1,72 mg/kg; zearalenon – 0,005…0,3 mg/kg; Т-2 toxin of 0,005…1,4 mg/kg, aflatoxin 0,005…0,02 mg/kg, ochratoxin – 0,005…0,048 mg/kg. At feeding with mycotocxins even in maximum concentration limit, obligatory control of the clinical and biochemical status of animals is required to a horned cattle of forages.
Keywords: mycotocxins, rough and juicy forages, a horned cattle.

UDK 619:616-085:618.3-008.6:636.4
Complex therapy and prophylaxis of gestosis at sows
A.G. Nezhdanov, V.N. Kotsarev, Yu. N. Alyohin, N.A. Gorohov
Summary. In two experiences оn 56 pregnant Large White sows, the weight of a body 180-230 kg defines efficiency of complex therapy and prophylaxis gestosis at sows by appointment of a complex of pharmacological means. In the first experience on 25 animals in 103-105-day pregnancies with the complicated current efficiency of application intestevit, sodium thiosulfate, acetilsalicylic and ascorbic acids, glucose, a dry extract of an oak, bentonite, seledant, 20 %-solution sulfate magnesium for therapy of sows is defined at gestosis. In the second experience on 31 sows 85-90-day pregnancies without essential deviations from norm in a clinical condition efficiency of application intestevit, ascorbic and acetilsalicylic acids, glucose, bentonite and seledant for prophylaxis gestosis is defined. The diagnosis on gestosis was established by means of a tonometer of model UA F&L of manufacture by firms Compani Ltd (Japan), on hypertensia presence: systolic blood pressure more than 130 mm Hg and more and diastolic – 90 mm Hg and more, a proteinuria revealed by means of diagnostic strips «Albu PHAN» firms PLIVA-Lachema (Czechia), at presence in urine of protein more than 0,3 g/l, plentiful salivation, a gnash teeth, poses of «a sedentary dog». An estimation of therapeutic and prophylaxis efficiency of complexes of preparations appointed to sows spent on aforementioned indicators, and also on character of labors and postnatal period, a condition of a mammary gland, viability of piglets.  Appointment to sows of course of treatment promoted decrease systolic and diastolic blood pressure upon 10,8-15,2 %, to reduction of the content of protein in urine in 1,9 times, to reduction of a duration of delivery on 1 h 29 minutes, the primary powerless labors – in 2,5 time, placenta detention – in 2,7 times, mortinatality in 2,2 times, births underdeveloped piglets – in 1,46 times, diseases of postnatal illnesses – in 2,9 times, affection of a mammary gland a subclinical mastitis – in 2,0 times. Appointment to sows of a complex of pharmacological means for prophylaxis promoted display reduction gestosis at sows 4,1 times, the primary powerless labors – in 2,9 times, mortinatality – in 2,21 times, births underdeveloped piglets – in 1,58 times, diseases of postnatal illnesses – in 2,2 times, affection of a mammary gland a subclinical mastitis – in 1,78 times.
Keywords: sows, gestosis, preparations, therapy, prophylaxis.

UDK 619 : 615.28 : 618.7 : 636.4
Application «VIAPENUM» for treatment a metritis-mastitis-agalactia and preventive maintenance of a postnatal pathology at sows
L.V. Cheskidova, V.N. Kotsarev
Summary. For treatment of sows with a obstetrics and gynecologic pathology a lot of actions with use of antibacterial preparations is required. Therefore on lathering to a basis the new complex antimicrobic preparation «Viapenum». In this connection the purpose of our work was the clinical estimation of a preparation for treatment a metritis-mastitis-agalactia and preventive maintenance of a postnatal pathology at sows. Apparently from the analysis of the received data, the maximal medical effect of a «Viapenum» at a metritis-mastitis-agalactia is shown at triple intrauterine introduction (95,3 %) in a doze 60 g on an animal, nevertheless, double application of a preparation also shows high enough therapeutic effect (89,7 %), that on 9,6-11,9 % above a preparation of comparison. At application of a «Viapenum» to sows with the preventive purpose, it has been established, that postnatal illnesses have decreased in 2,6 times in comparison with the negative control and over 1,5 times in comparison with «Enrocidum», including endometritis – in 2,1 times and 1,3 times, accordingly, and ММА – in 4,5 times and 1,9 times, accordingly. Results of the lead researches testify also that intrauterine introduction of a «Viapenum» in 4-6 hours after опороса reduces defeat of sows by a subclinical mastitis in 2,5-1,4 times in relation to the negative control and a preparation of comparison («Enrocidum»). 
Keywords: viapenum, sows, a metritis-mastitis-agalactia, treatment, preventive maintenance.

UDK 619:615.28:616.34:636.4-082.35
Medical efficiency of new complex antimicrobic preparations during gastroenteric diseases bacterial etiology in piglets 
O.V. Kazimirov, Yu.N. Brigadirov, M.L. Berdnikov, S.V. Borisenko, E.V. Mikhailov, A.N. Modin
Summary. Plural medicinal stability of pathogenic, conditional – pathogenic microorganisms of animals circulating in populations makes necessary search of optimum medical products for struggle against gastro-enteric illnesses of pigs bacterial etiology. Were are two series of experiences on pigs of different age. For the first experience 1168 pigs 79-84 day time age have been picked up. Bacteriological researches of a pathological material from is compelled – killed and falling pigs allocate activators Escherichia coli serology variants О139, 020, О141, causing swollen illness of pigs, Enterococccus faecalis and Salmonella choleraesuis. In clinical tests used preparations Thetragold-oral in a doze of weight of a body of 0,2 г/kg. Its therapeutic efficiency has made 94,4 %, Diocsinor an oral solution in a doze of kg of weight of a body of 0,5 ml / 10, therapeutic efficiency has made – 92,6 %. Thilocolinum oral in a doze 0,5 г/10 kg of weight of a body its therapeutic effect has made 91,1 % and thiamulin+niphulin (the circuit of a facilities) the medical effect has made – 88,7 %. For the second experience 292 pigs of 0-28 days have been picked up, bacteriological researches be make diagnosted activators colibactheriosis – E. coli 020, 078 and streptococcosis – Str. Suis. In clinical experiences applied Diocsinor an oral solution in a doze of kg of weight of a body of 0,5 ml / 10, the therapeutic effect has made 92,5 %, Thetragold-oral in a doze 2 г/10 kg of weight of a body his{its} medical effect has made – 83,9 % and at Thilocolini-O it has made – 82,6%, Magcolistinum (the circuit of a facilities) therapeutic efficiency has made 76,3%.
Keywords: pigs, gastroenteric diseases, complex preparations, bacterium.

UDK 619:616-002.828:636.4
Mycoplasma infection in pigs
L.I. Efanova, A.V. Stepanov, M.M. Sviridov, О.А. Manzhurina
Summary. All-Russian Veterinary Pathology Pharmacology and Therapy Research Institute Results of retrospective monitoring of circulation of pathogenic mycoplasmas at the pigs, spent by methods enzyme immunoassay and polimerazno chain reaction, in 26 pig-breeding economy of the Belgorod, Voronezh, Kursk, Lipetsk, Murmansk, Oryol, Rostov, Ryazan, Tambov and Yaroslavl areas are presented. Biological tests (blood whey, sperm and vaginal washouts) and рathological material (deadborn, fallen and forcedly killed animals) received from pigs of various technological groups and age (male pigs, sows, pigs to 1, 2, 3 and are more senior 3 monthly age, repair pigs) are investigated. Wide circulation of pathogenic mycoplasmas (96,2%), including Mycoplasma hyopneumoniae (88,5%) in the surveyed pig-breeding economy is established. DNA of pathogenic mycoplasmas was allocated from рathological material from pigs 2 – 3 monthly age (60-85%), is more rare from pigs to 1st and is more senior 3 monthly age and repair pigs – 30-47%, and also from vaginal washouts of sows with a reproductive pathology (9,1%) and sperms of male pigs (2%). Antibodies to Mycoplasma hyopneumoniae were found out in whey of blood in male pigs – 43,2%, sows – 56%, repair pigs – 27,7%; pigs till 1 month – 43,8%, from 1 about 2 months – 0%, from 2 about 3 months – 66% also are more senior 3 months – 33,2%. Vertical and horizontal transfer of pathogenic mycoplasmas among pigs, their participation in a reproductive pathology, and also in the pre-natal 54,1%) and postnatal (55,8%) is shown their destruction. 
Keywords: pigs, mycoplasma infection, enzyme immunoassay, polymerase chain reaction.

UDK  619:615.33:616-002.153;636.4-082.35
Improved therapeutic efficacy dioxynor in respiratory diseases of pigs in combination with lipoton 
A.G. Shakhov, L.Yu. Sashnina, D.V. Fedosov
Summary. The purpose of the research is the study of therapeutic efficiency of complex drug dioxinor that is based on dioxidin and norfloxacin, in combination with respiratory illnesses lipotonom in piglets. Pasteurella multocida and Salmonella cholerae suis were isolated during the bacteriological study of pathological material from the killed for diagnostic purposes pneumonia piglets. For the treatment of animals (n = 11) dioxinor was used intramuscularly within 10 days of once-daily dose of 0.1 ml / kg body weight separately and in a similar pattern (n = 11) in combination with lipoton, which was injected intramuscularly at a dose of 0.075 ml / kg body weight at 1, 3, 5 and 7 days of treatment. The use of Dioxinor ensured the recovery of 81.8% of animals, in the drug treatment in combination with lipoton therapeutic efficiency was higher by 9.1% to 90.9%. There was a trend towards normalization of morphological and biochemical parameters of blood in animals after the recovery. Antibiotic therapy in combination with lipoton helped to stabilize liver function, reduced the cytotoxic effect of dioxinor on its cells, largely normalized indices reflecting the state of LPO-AOD, which indicates on the hepato-, membrane protection of lipoton. The high therapeutic efficiency of integrated antimicrobial agent dioxinor in combination with immunocorrigating drug lipoton at piglets’ respiratory diseases caused by an association of microorganisms was established.
Keywords: dioxynor, lipoton, treatment, piglets, respiratory diseases.

UDK 619:577.12:612.6:615.244:636.2.034
Correction of a metabolic profile and reproductive function of cows by the preparations hepatoprotective actions
A.G. Nezhdanov, V.A. Safonov, E.V. Shishkina, G.G. Chusova, I.S. Tolkachyov
Summary. To study influence on the haemomorphological and biochemical status of pregnant cows and their diseases postnatal endometritis a preparation of Gepatoprotektor. Researches are executed on 86 highly productive cows of red-motley breed at the age of 4-6 years. Animals have been distributed on 3 groups. To 31 cow during 2 … 3 weeks of the prenatal period and 3 … 4 weeks of the postnatal period fed Gepatoprotektor in a dose 300 g, to 27 cows 55-60 and 25-30 days prior to expected calving intramuscularly injecthioned Selemag in a dose of 5 ml on 100 kg of weight of a body. 28 cows have made group of negative control. Studied a clinical condition of animals with definition of arterial pressure and indicators of a proteinuria, the haemomorphological and biochemical status before statement of experience and 4-6 days prior to calving, histostructural a condition fetal parts of the placenta received after deducing of a fetus, postnatal complications. Appointment to cows of Gepatoprotektor and Selemag was accompanied by change hemopoesis and the biochemical status shown by decrease of the maintenance of leukocytes on 12,3-18,9 %, eosinophiles in 2,8-2,1 times, to increase in quantity of neutrophils at 24,2-12,8 %, thrombocites on 35,6-12,5 %, glucose on 28-36 %, vitamin E on 48,5-58,0 %, vitamin C in 2,3-2,7 time, selenium on 75,4-78,4 %, processes of a metabolism of protein became more active, activity peroxide oxidations of lipids was stabilized or has decreased. Gepatoprotektor shows more expressed influence on a metabolism of protein, and Selemag – more expressed antioxidant action. At appointment of Gepatoprotektor the increase villus of chorion on 47,7-65,3 % and potion part their epithelium on 14,4 % is marked. Preparations have provided decrease in arterial pressure upon 8,2-10,9 %, concentration of protein in urine on 35,7-37,4 % and diseases of cows postnatal endometritis in 1,48-1,66 times.
Keywords: cows, gepatoprotektor, selemag, metabolism, reproductive function.

UDK 619:618.19-.002:579.252.55:636.2-05.26:636.2-053.31
Effect of drug prevention mastitis in dry cows on haematological, biochemical and immunological parameters of mother and newborn calves
Y.S. Kluchnikova, N.T. Klimov, E.V. Tyurina
Summary. The article presents data on the impact of intracisternal administration of prolonged antimicrobial Orbenina DS clinically healthy cows at the end of lactation on the morphological, biochemical and immunological parameters of maternal and newborn calves. It is established that the studied blood parameters of cows in both groups during the experiment were within normal limits and did not differ significantly. However, in animals treated with Orbeninom DS, and bactericidal activity of blood serum lizotsimnaya in the middle of the dry period was lower by 7.2%, respectively, and 27.8%, compared with intact. After calving in treated animals Orbeninom DS content of total immunoglobulins and bactericidal activity of blood serum lizotsimnaya was also lower – 19.2%, 18.4% and 34.9% respectively. It was determined that the introduction of Orbenina DS, the lame cows running a negative effect on the newborn young, which is manifested in the reduction of their blood concentrations of total protein of 11.4% (P <0.1), gamma globulin – by 58.8% (P <0.01), total immunoglobulin – by 39.6% (P <0.01), gamma-GT – 44.6% (P <0.1), and bactericidal activity of blood serum lizotsimnoy to 41.4% ( P <0.01) and 10.1% (P <0.5), respectively, and increased concentration of albumin – by 15.2% (P <0.05). These changes in the biochemical and immunological status of newborn calves are probably associated with inhibition of immunological reactions in mothers due to intracisternal injection of cloxacillin for two months before calving. Thus, the results of studies suggest that the intracisternal administration of antimicrobial agent (Orbenin DS) clinically healthy animals at the end of lactation affects the biochemical and immunological status of newborn calves.
Keywords: cows, calves, antibiotic resistance. 

UDK 619:618.14-002:618.7:636.2
Improved methods for the treatment of acute postpartum endometritis in cows
S.V. Chupryn, D.A. Erin, V.I. Mikhalev, L.I. Efanova
Summary. Acute post-partum endometritis in cows on the farms of Voronezh, Belgorod and Orel regions, is widespread and is registered in 23,2-51,6% of hotels in cows. Therefore, the development and improvement of methods of treatment is important. The aim of this study was to improve the treatment of acute postpartum endometritis is carried out as through the use of antimicrobial agents that suppress the growth of microflora in the uterus and through the mobilization of host's defenses by increasing its non-specific resistance. Most effective for the treatment of acute postpartum endometritis in cows are antimicrobial agents in foam-based application that increases the effectiveness of treatment for 6,8-15,1% compared with the means on the basis of dimethyl sulfoxide and water-based. The efficiency of using funds obschestimuliruyuschey nonspecific therapy (emulsified denatured placenta and 7% Ichthyol) was 77,8-80,0%, which is 17,8-20,0% compared with animals who have only used antimicrobial and myotropic drugs. Additional parenteral administration of antibiotics to cows, in particular nitoksa, enhances the therapeutic efficacy in 16,4-19,7% reduction in the period from calving to conception in 7,7-14,4 (P<0.05) days and fertilization rate - to 0,31-0,39. The greatest therapeutic effect of treatment of acute postpartum endometritis obtained by using a complex method that involves the use of two obschestimuliruyuschey nonspecific (PDE and ASD-2F), symptomatic (sinestrol and oxytocin) and causal (tetrameter and nitoks) therapy, which provides recovery of 92,3% of animals followed by insemination 91,7% after an average of 55,9+4,91 days. 
Keywords: cows, endometritis, therapy. 

UDK 619:577.1:616.24-002.153:636.2-053.81
Shakurov novocaine block effect on biochemical parameters of exhaled breath condensate and blood in calves with bronchopneumonia
A.E. Chernitskiy, A.I. Zolotarev
Summary. Our object was to study the effect of Shakurov novocaine block on biochemical parameters of exhaled breath condensate (ЕВС) and blood in calves with bronchopneumonia, and the therapeutic efficiency. It was determined that Shakurov novocaine block in addition to antibiotic and substitution treatment of calves with bronchopneumonia allows to recover some biochemical parameters of exhaled breath condensate, increase functional activity of the organism antioxidant protection system, reduce lipid peroxidation products in blood and endogenous intoxication level. So, after this treatmentof calves with bronchopneumonia the activity of gamma-glutamyltransferase in EBC and the content of EBC calcium reduced by 41.0 and 14.7% (p<0.05) accordingly in comparison with the initial level (before treatment); the activity of glutathione peroxidase increased by 40.2% (p<0.05), the content of plasma malonic dialdehyde and substances with low and average molecular weight in calves reduced by 31.3 and 7.5% respectively in comparison with the initial level. After this complex treatment the minute volume of EBC decreased by 18.5 (p<0.05) and reached the level like in a healthy calves. This helped to reduce the recovery period by 0.6 days (p<0.01) and to increase the number of animals recovered after treatment by 8.4% (p<0.05) in comparison with calves treated with means of causal and substitution therapy. In conclusion, in the present study we identified that Shakurov novocaine block in addition to common treatment of calves with bronchopneumonia not only allows shorten calves recuperation period and to improve treatment efficiency in general but also promotes to recover the respiratory water release and metabolic lung function.
Keywords: Shakurov novocaine block, bronchopneumonia, calves, exhaled breath condensate, system of organism antioxidant protection, endogenous intoxication.

UDK 619:577.121:615.28
Expression of xenobiotic metabolism phases i and ii enzymes during antivicrobial drugs administration
E.V. Bratchenko, O.Yu. Fomenko
Summary. The aim of this work was to study the relative expression levels of xenobiotic metabolism phases I and II enzymes in rat liver during administration of antimicrobial agents of different pharmacological groups (tylosin and tsiminal). Expression level of the genes of interest was determined using real time polymerase chain reaction. GAPDH was used as house-keeping gene. Differences reliability was determined by pairwise comparisons using Student’s t-test (p ≤ 0,05). It was shown that the usage of tylosin at a dose of 2.4 mg per 100 g of body weight cause a significant induction of CYP1A1 and CYP1A2 genes. The level of their transcripts in the liver was 3,16 ± 0,12 and 8,06 ± 0,4 fold than in the control group. In this case also there was a slight increase in expression of CYP2B1 and CYP3A1 genes (in 1,46 ± 0,04 and 1,82 ± 0,09, respectively). There were no statistically significant differences in expression levels between control group and rats treated with «Tsidisept-O». We can conclude that in contrast to tylosin, the administration of antimicrobial agents based on tsiminal did not exert an inducing effect on xenobiotics metabolism gene expression patterns and did not lead to imbalance in microsomal and free radical oxidation systems. 
Keywords: expression, antimicrobial drugs, liver, cytochrome P450, glutathione-S-transferase.

UDK 619: 579.252.55: 578.81: 615.28
The formation of resistance and restore sensitivity of bacteria to composite antibiotic specimen dioxynor
L.Yu. Sashnina
Summary. One way to prevent the formation of resistance to antibiotics or reduce its promising application of bacterial infections of complex antibiotics. The purpose of research - the study of the development of resistance and restore sensitivity in Escherichia, Salmonella, Staphylococcus aureus and Pasteurella to dioxinor developed on the basis of dioxidin and norfloxacin. It is recommended for use as a means ethiotropic in the gastro-intestinal and respiratory diseases of young farm animals. The study of the development of resistance of microorganisms to dioxinor performed by culturing them in the meat-peptone broth (MPB) containing increasing subbacteriostatic concentrations of the drug. In cultures of microorganisms degree of resistance to the drug resistance was assessed by the ratio - the ratio of the maximum, not hinder the growth of bacteria concentration to the original. The stability of acquired bacterial resistance and restore sensitivity to dioxinor studied by successive passages of microorganisms in the MPB that contains no drug. The investigation has found a high antimicrobial activity dioxinor: minimum bacteriostatic concentration for Escherichia and Salmonella was 0.39 mg / ml of Staphylococcus aureus - 1.56 micrograms / ml and Pasteurella - 0.78 micrograms / ml. The formation of resistance of microorganisms to the drug has been slow rate which was at the Escherichia and Salmonella 8 (after 40 passages), Staphylococcus aureus and Pasteurella - 4 (30 passages). Acquired resistance to microorganisms dioxinor is an unstable trait, and restore their sensitivity to the drug occurred relatively quickly: the Escherichia and Salmonella after 60 passages, S. aureus and Pasteurella after 50 passages. The results obtained justify the appropriateness of including dioxidin and norfloxacin in the complex preparation dioxinor.
Keywords: dioxynor, dioxydin, norphloxacin, resistance, escherichia, salmonella, staphylococcus aureus, pasteurella.

UDK 619:615.281:577.1:636.028 
The influence of the drug floropen on hematologic and biochemical parameters of blood in laboratory animals
I.V. Bryukhova, G.G. Chusova, Т.Е. Rogachevа, A.V. Topolnitskaya
Summary. Pre-clinical tests of medical preparations are obligatory and one of the major stages of their creation. So, it was carried out a study of influence of a preparation floropen on haematological and biochemical parameters of the blood of laboratory animals in chronic experience.  Analysis of data obtained in the study of the toxic properties of floropen with the long-term subcutaneous application within 21 days of white rats, has shown that the drug in doses of 315,0 mg/kg and 788,0 mg/kg has no negative effect on haematological and biochemical parameters of the blood of animals. During the 21-day subcutaneous injection of the preparation in the dose of 1575 mg/kg body weight in rats of experimental group reliably increased content in the blood serum creatinine – on 18,3 %, urea – on 26,2 %, activity of aspartate aminotransferase and alanine aminotransferase – accordingly on 19,1 and 24,6 % in comparison with animals of control group. At the same time, fluctuations in the values of these indicators were within the physiological norm for this type of animals. Thus, on the basis of the results obtained from chronic experience, we can conclude that floropen in doses 315,0 mg/kg and 788,0 mg/kg has no negative effect on morphological and biochemical indicators of the blood of animals, and in the dose of 1575,0 mg/kg, these changes are minor and are reversible.
Keywords: floropen, laboratory animals, chronic toxicity, hematology, biochemistry.

UDK 619:615.281:615.9:612.6:636.028
The influence of the preparation eritroksid on the reproductive function of white rats
T.A. Paninа, I.Yu. Kashapova, E.I. Ponomareva
Summary. The system of assessment of safety of medicinal products, adopted in the Russian Federation, along with general toxicological researches, is the study of specific types of toxicity, such as genotoxicity, immunotoxicity, allergenicity, reproductive toxicity. In this paper embryotoxic and teratogenic action of an integrated drug eritroksid is studied. The received experimental data testify that the drug is not induce death of embryos, has no negative impact on the development of the offspring and investigated parameters were consistent to physiological values for the given species. The conducted morphological researches have shown absence of development anomalies of an internal organs and a skeleton of foetuses born from rats of experimental groups. Substantial distinctions in rat fertility of experimental and control groups it is not established. The average number of foetuses on the female in the control group equaled 9.7±0.4, and in rats receiving eritroksid in the dose 0.3 ml/kg of body weight by 5 and 15 days of pregnancy – 9,9±0,6 and 9,7±0,3, respectively. Postnatal development of the offspring in the experimental and control groups are characterized by a high survival rate of 86,4-88.3%. The infant rats born from females of experimental groups, did not differ from infant rats of control females. Analysis of the physical development of the offspring – the timing of the auricles detachment, the appearance of the hair, the appearance of new tools, the opening of the eyes, etc., as well as the dynamics of body weight and height rats – not reveal any deviations from the norm. So, detachment of the auricles of infant rats of control group was on 2,74±0,06 days, of experimental group – on 2,80±0,04 and 2,83±0,07 days. The appearance of the primary hair was happening on 5,91±0,05 days (control), 5,86±0,07 and 5,79±0,08 days (experimental). Thus, for intramuscular administration to rats in different periods of embryogenesis in the dose 0.3 ml/kg of body weight eritroksid does not have embryotoxic and teratogenic action.
Keywords: reproductive toxicity, eritroksid, development of the offspring.

UDK 621.314.26
Calculation method of resonant high voltage transformer
D.S. Strebkov, I.R. Izilyaev
Summary. The article describes the method of calculation of resonant high voltage transformer used in a resonant system of transmission of electrical energy. It is proposed a constructive solution to improve the efficiency of transformation and transmission of electric energy, as well as to increase the electrical insulation strength of high-voltage winding of a resonant high voltage transformer.
Keywords: resonant high voltage transformer, extra-coil, resonator, inductance, capacitance, quality factor.

UDK 621.37:631.5
Theoretical justification of efficiency and quality of agricultural products smoking in the electric fumatory
A.G. Vozmilov, P.S. Rusin, N.I. Smolin, Yu.N. Varfalomeev
Summary.  The article discusses theoretical aspects of calculation of the main parameters of the electric fumatory ensuring the increase in efficiency and quality of agricultural products smoking through the coarse purification of air-flue mixture of large particles and the more even distribution of the fine-dispersed part of this mixture on smoking products. The peculiarities of charging and sedimentation of air-flue mixture particles on the smoking product, depending on their sizes and air-flow rate, are distinguished.
Keywords: electric smoking, air-flue mixture, electric fumatory, particle distribution evenness, power inputs decrease.

UDK 631.3
The results of field research stabilization of the vomer depth on the tube stand
I.P. Lapshin, S.N. Kokoshin
Summary. With the simultaneous cultivation of the soil and sowing the working body of the force of resistance, which affects the uniformity of the depth movement paws. Compliance with the requirements of farming in the depth of the combined Tine vomer with simultaneous pre-sowing tillage and possibly the use of flexible pipe racks. This design lets you move the paw in the vertical direction to the required distance, compensating for unevenness of the depth, caused by the resistance of the soil. To use the tubular element in a design counters vomer should determine the nature of the influence of the resistance of the soil and the pressure applied to the inside of the element to move the paws, which is the purpose of field research. The results of these studies represent the relationship between the movement paws of the tubular to stand under pressure by the resistance of the soil and speed of the unit. It is established that at the speed of the unit from 1 to 5.1 km / h the resistance of soil to create pressure in the tubular element of 14-15 MPa, increased by 0.3 and 0.45 kN respectively. This proves that under the pressure foot deepens. The results of field tests showed that the use of tubular stands in the construction of vomer can achieve the stability of the paw of up to 89% of the total length of estrus.
Keywords: vomer, tubular stand, seeding depth, movement, stabilization of motion.

UDK 665.937.6:591.471.442.4I:664.66
Development of new species of bakery products using antler raw 
G.I. Tyupkina, K.A. Layshev
Summary. The results of investigations of obtaining new types of bakery products using ultrafine powder of reindeer antlers. A technology for preparation of dough and baking bread new species with the addition of soot from reindeer antlers. Found that among the most balanced of prototypes by the presence of essential amino acids are the bread and biscuits containing 0.50% soot from reindeer antlers on the mass of flour. Application of the developed technologies leads to new types of functional foods high in nutritional deficit in human nutrition of micro and macro to balance the mineral metabolism.
Keywords: deer antlers, processing, biologically active substances, products of functional assignments.

UDK 664.864
Mushroom drying in non-stationary conditions
A.L. Vereshchagin, I.V. Shcheglova
Summary. The results of studies regarding the changes in the mushrooms composition with the use drying in the nonstationary conditions are given. The positive influence of vacuum drying on the adsorptive and microbiological properties of mushrooms is discovered.
Keywords: mushrooms, nutritional value, vacuum-pulse drying, explosive self-hydrolysis, water absorption, microbiological dissemination, heavy metals.